Journal Abbreviation: PLOS MED
                Journal ISSN: 1549-1676
| Year | Impact Factor (IF) | Total Articles | Total Cites | 
| 2024 (2025 update) | 9.9 | - | 43413 | 
| 2023 | 10.5 | 136 | 42360 | 
| 2022 | 15.8 | - | 46220 | 
| 2021 | 11.613 | - | 47916 | 
| 2020 | 11.069 | 325 | 42445 | 
| 2019 | 10.500 | 249 | 32312 | 
| 2018 | 11.048 | 182 | 30689 | 
| 2017 | 11.675 | 204 | 24232 | 
| 2016 | 11.862 | 189 | 22665 | 
| 2015 | 13.585 | 97 | 20499 | 
| 2014 | 14.429 | 128 | 18649 | 
| 2013 | 14.000 | 118 | 16975 | 
| 2012 | 15.253 | 115 | 14820 | 
| 2011 | 16.269 | 126 | 12574 |